Hypoglycaemic animal activity studies of Cucurbita maxima Seed extracts with streptozotocin formulation

---

Original Article

Author Details : Ravi Pratap Pulla*, Shubhadip Nandi, Kush Biswas, Anushree Mistry, Subhoneel Dolui

Volume : 12, Issue : 1, Year : 2024

Article Page : 42-45

https://doi.org/10.18231/j.jpbs.2024.007

Suggest article by email

Get Permission

---

Abstract

The Cucurbita maxima which generally known as pumpkin, belongs to the family Cucurbitaceae. The Cucurbitaceae plants are known as cucurbits. They are developed in tropical and subtropical zones. Cucurbit species include pumpkins, squashes, gourds and melons. Streptozotocin was found from soil bacterium (Streptomyces achromogenes) which is a compound in nature having antibacterial properties. This is a glucosamine nitrosourea containing compound and furthermore goes about as alkylating specialist that causes DNA harm and shows poisonous nature to the islet β-cells.
Carbonium particles are the degradable type of Streptozotocin (STZ) and alkalyting purine and pyrimidine bases are adducted structure the DNA. Glibenclamide hinders of the K+ particles channels which prompts depolarization of β-cells and discharged insulin. Streptozotocin makes pancreas enlarge and finally causes degeneration in Langerhans islet β-cells and prompts trial diabetes.
It additionally changes typical digestion in diabetic rodents (rats) in correlation with ordinary rodents. The current exploration manages the different sorts of concentrates like petrol ether separates, ethyl acetic acid derivation concentrates, and alcoholic concentrates of seeds of Cucurbita maxima (Cucurbitaceae) on Streptozotocin prompted diabetic rodents.
The petrol ether separates, ethyl acetic acid derivation and alcoholic concentrate were viewed as diminished the blood glucose level to 163.55 ± 4.23 mg/dL, 91.50 ± 1.93 mg/dL and 189.91 ± 1.89 mg/dL on 36 hour of the review (p<0>

Keywords: Cucurbita maxima, β-cells, Streptozotocin, Diabetes, Induced Rats

How to cite : Pulla R P, Nandi S, Biswas K, Mistry A, Dolui S, Hypoglycaemic animal activity studies of Cucurbita maxima Seed extracts with streptozotocin formulation. J Pharm Biol Sci 2024;12(1):42-45

This is an Open Access (OA) journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.