Formulation development and invitro evaluation of fentanyl patches for transdermal drug delivery system

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Original Article

Author Details : K. Sandhya Rani, Sunil Reddy, A. Venkatesham

Volume : 5, Issue : 5, Year : 2017

Article Page : 188-193

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Abstract

Oral drug delivery system has various drawbacks like poor bioavailability due to hepatic metabolism (first pass) and the tendency to produce rapid blood level spikes (both high and low), leading to a need for high and frequent dosing, which can be both cost prohibitive and inconvenient. In present study transdermal drug delivery of Fentanyl was developed to overcome the first pass metabolism and to reduce frequency of dosing compared to oral route. Matrix type of transdermal patches were developed by using polymers Eudragit-L100, HPMC K4M and HPMC K15M. Transdermal patches were prepared by employing solvent casting method. Propylene glycol and Tween80 were selected as permeation enhancer and plasticizer. Formulations were prepared with the varying concentrations polymers ranging from F1-F6, and all the formulations were evaluated for various physical parameters, invitro drug release studies by using dialysis membrane. Among all the formulations F6 formulation was found to be best and shown 96.97% drug release in 12 hours. For F6 formulation release kinetics was applied and it was observed that the formulation was following peppas mechanism of drug release. Drug excipients compatibility studies were carried out by using FT-IR and it was observed that they were no interactions.

Keywords: Fentanyl, Transdermal Patch, Solvent Casting Method, Dialysis Membrane, Release Kinetics, Compatibility Studies, FT-IR Studies.

How to cite : Rani K S, Reddy S, Venkatesham A, Formulation development and invitro evaluation of fentanyl patches for transdermal drug delivery system. J Pharm Biol Sci 2017;5(5):188-193

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