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- DOI 10.18231/j.jpbs.2025.004
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CrossMark
- Citation
A systematic review of potential anticancer activities of Muntingia calabura L. With a focus on cellular and molecular mechanisms
Please review the following correction notices associated with this article:
Retraction
This notice is to inform you that the article titled “A systematic review of potential anticancer activities of Muntingia calabura L. With a focus on cellular and molecular mechanisms” (DOI: https://doi.org/10.18231/j.jpbs.2025.004), published in Volume 13, Issue 1, Year 2025 of the Journal of Pharmaceutical and Biological Sciences, has been updated and Retraction is generated for the same after receiving formal complaint from the Author regarding incomplete structure of the work and conflict regarding publication in between authors.
In light of these issues, the decision has been made to retract this article, to uphold the integrity of the journal and its publication standards. We sincerely apologize for any inconvenience this may have caused to our readers.
Thank you for your understanding.
View Document Effective: August 05, 2025
- Author Details:
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Muna Hamoud Alseaghi
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Razana Mohd Ali
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Muhammad Nazrul Hakim Hakim
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Zainul Amiruddin Zakaria
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Melati Khalid *
Medicinal plants have been extensively explored for their chemopreventive and antiproliferative properties. Among these, Muntingia calabura has emerged as a promising candidate due to its ability to modulate various signaling pathways involved in cancer progression and suppression. This includes interactions with multiple cell signaling molecules that regulate cancer formation and development. This review aims to critically evaluate the anticancer properties of M. calabura across different cancer types. A systematic literature search was performed across major scientific databases, including ScienceDirect, PubMed, and Scopus. Studies were selected based on predefined inclusion criteria using the keywords "Muntingia calabura", “M. calabura”, “anticancer” and "cancer." A total of 13 studies met the eligibility criteria and were analyzed for this review. Evidence from the reviewed studies highlights the anticancer effects of M. calabura extracts, which include inhibition of inflammatory and apoptotic pathways. The modulation of dysregulated signaling cascades, such as the LOX, XO, and RAF1 pathways, was shown to contribute significantly to its anticancer activity. The findings support the potential application of M. calabura and its phytochemical constituents in cancer prevention and therapy. However, further in-depth studies are necessary to identify its bioactive compounds and elucidate the mechanisms underlying its anticancer effects for clinical translation.
Keywords: Muntingia calabura, Anticancer, Phytochemicals, Flavonoids