Evaluation of antidiabetic activity of ethanolic extract of roots of pterocarpus marsupium in streptozotocin induced diabetic rats

• Author Details:   
• Abhishek N.
• Karunakar Hegde
• Chaithra Amin B
• Ajay Kumar

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The present study evaluates the effect of ethanolic bark extract of P.marsupium in streptozotocin induced diabetic rats. Diabetes was induced in rats by administering streptozotocin (50mg/ kg) intraperitonially (ip). Animals were divided into five groups (n=6) receiving different treatments: Group I: vehicle (normal Control), Group II: (diabetic control), Group III: standard antidiabetic drug glibenclamide (1 mg/ kg bw, orally), Groups IV and V: ethanolic root extract treated (200 mg and 400 mg/ kg bw, orally respectively). Blood samples were collected and analyzed for blood glucose, SGPT and SGOT after 28 days of the treatment. The ethanolic root extract of P.marsupium at the dose level of 200 and 400 mg/ kg bw, produced significant reduction in blood glucose and serum enzymes (SGPT and SGOT) level and body weight improves by the extracts at dose of 200mg/kg and 400mg/kg during treatment period. The present investigation thereby reveals the anti-hyperglycemic potential of ethanolic root extract of P.marsupium.

Keywords: Diabetes mellitus, Streptozotocin, Glibenclamide, Pterocarpus marsupium, Blood glucose level, Body weight, Anti-diabetic activity